Mark T Gladwin Selected Research

Nitrite Reductases (Nitrite Reductase)

4/2011	Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats.
8/2008	Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis.
7/2008	Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury.
2/2008	Nitrite reductase activity of hemoglobin S (sickle) provides insight into contributions of heme redox potential versus ligand affinity.
1/2006	Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation.

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Mark T Gladwin Research Topics

Disease

88	Sickle Cell Anemia (Hemoglobin S Disease) 01/2022 - 02/2002
82	Hemolysis 11/2022 - 12/2002
71	Pulmonary Hypertension 12/2021 - 07/2003
40	Hypoxia (Hypoxemia) 05/2022 - 12/2003
19	Pulmonary Arterial Hypertension 05/2022 - 09/2007
19	Ischemia 01/2021 - 05/2005
17	Reperfusion Injury 01/2022 - 07/2004
14	Inflammation (Inflammations) 01/2022 - 03/2003
11	Heart Failure 01/2021 - 01/2015
11	Tricuspid Valve Insufficiency (Insufficiency, Tricuspid Valve) 01/2020 - 11/2009
11	Hemolytic Anemia 01/2020 - 07/2003
10	Hypertension (High Blood Pressure) 01/2020 - 02/2004
9	Pain (Aches) 01/2021 - 07/2006
9	Infarction (Infarctions) 12/2020 - 05/2005
7	Lung Injury 01/2022 - 02/2014
7	Infections 01/2021 - 02/2013
7	Thalassemia 01/2021 - 01/2008
6	Vascular Diseases (Vascular Disease) 01/2021 - 01/2003
6	Malaria 01/2021 - 09/2010
6	Anemia 11/2020 - 03/2005
6	Vascular System Injuries 07/2011 - 03/2003
5	Stroke (Strokes) 05/2022 - 02/2008
5	Hypertrophy 05/2022 - 01/2010
5	Pneumonia (Pneumonitis) 01/2021 - 07/2013
5	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021 - 07/2015
5	Acute Chest Syndrome 01/2020 - 03/2003
5	Thrombosis (Thrombus) 01/2020 - 01/2006
5	Disease Progression 01/2018 - 11/2009
5	Myocardial Infarction 07/2008 - 05/2005
4	Glucosephosphate Dehydrogenase Deficiency 11/2022 - 07/2010
4	Poisoning 01/2021 - 12/2016
4	Shock 01/2021 - 05/2005
4	COVID-19 12/2020 - 01/2020
4	Insulin Resistance 01/2020 - 07/2015
4	Dehydration (Water Stress) 12/2019 - 10/2015
4	Left Ventricular Dysfunction 01/2019 - 11/2009
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2019 - 01/2011
4	alpha-Thalassemia 04/2017 - 05/2008
4	Priapism 03/2017 - 03/2006
4	Myocardial Ischemia (Ischemic Heart Diseases) 01/2014 - 07/2006
4	Hemoglobinopathies 04/2012 - 04/2005
3	Heart Arrest (Cardiac Arrest) 01/2021 - 09/2009
3	Sepsis (Septicemia) 01/2021 - 01/2018
3	Hyperglycemia 01/2020 - 02/2016
3	Pulmonary Embolism 11/2019 - 12/2006
3	Carbon Monoxide Poisoning (Poisoning, Carbon Monoxide) 01/2018 - 12/2016
3	Lung Diseases (Lung Disease) 01/2018 - 06/2007
3	Acute Lung Injury 03/2017 - 12/2002
3	Chronic Renal Insufficiency 03/2017 - 03/2014
3	Obesity 01/2017 - 03/2014

Drug/Important Bio-Agent (IBA)

71	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2021 - 02/2002
69	Hemoglobins (Hemoglobin)IBA 11/2022 - 12/2002
56	NitritesIBA 01/2020 - 12/2003
20	Hydroxyurea (Hydrea)FDA LinkGeneric 04/2017 - 02/2002
19	Sickle HemoglobinIBA 01/2021 - 09/2002
18	Oxygen (Dioxygen)IBA 01/2021 - 09/2003
15	IronIBA 01/2021 - 05/2005
13	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 01/2005
13	Sodium NitriteIBA 08/2020 - 03/2004
12	Biomarkers (Surrogate Marker)IBA 01/2020 - 03/2006
12	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 12/2017 - 02/2004
12	Arginine (L-Arginine)FDA Link 10/2016 - 07/2003
11	Sildenafil Citrate (Viagra)FDA Link 12/2021 - 08/2005
10	Heme (Haem)IBA 01/2021 - 07/2004
10	NitratesIBA 12/2019 - 12/2005
10	Fetal Hemoglobin (Hemoglobin F)IBA 04/2017 - 01/2003
8	AnionsIBA 05/2013 - 01/2004
7	BilirubinIBA 11/2022 - 03/2006
7	Brain Natriuretic Peptide (Natrecor)FDA Link 12/2021 - 07/2006
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 07/2004
7	ArginaseIBA 01/2019 - 03/2005
7	pro-brain natriuretic peptide (1-76)IBA 01/2015 - 07/2006
6	Nitric Oxide Synthase (NO Synthase)IBA 01/2014 - 01/2003
6	Vasodilator Agents (Vasodilators)IBA 02/2011 - 10/2004
5	EnzymesIBA 01/2021 - 01/2006
5	Pharmaceutical PreparationsIBA 01/2020 - 12/2011
5	GlobinsIBA 12/2017 - 08/2009
5	Nitrite Reductases (Nitrite Reductase)IBA 04/2011 - 01/2006
4	Epoprostenol (Prostacyclin)FDA LinkGeneric 05/2022 - 01/2010
4	Semaxinib (SU5416)IBA 05/2022 - 02/2016
4	Oxidants (Oxidizing Agents)IBA 11/2020 - 12/2002
4	Carbon MonoxideIBA 01/2020 - 10/2007
4	LigandsIBA 01/2020 - 08/2011
4	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 02/2016
4	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 12/2011
4	Oxidoreductases (Dehydrogenase)IBA 12/2019 - 05/2008
4	Ferritins (Ferritin)IBA 01/2019 - 08/2011
4	HaptoglobinsIBA 01/2018 - 03/2006
4	Erythropoietin FDA Link 10/2016 - 08/2006
4	Superoxides (Superoxide)IBA 12/2014 - 03/2003
4	MyoglobinIBA 07/2012 - 07/2007
3	Soluble Guanylyl CyclaseIBA 01/2021 - 08/2012
3	Heme Oxygenase-1IBA 01/2021 - 07/2004
3	AntioxidantsIBA 01/2021 - 07/2004
3	Leptin ReceptorsIBA 01/2021 - 02/2016
3	NeuroglobinIBA 01/2020 - 12/2011
3	Biological ProductsIBA 12/2019 - 02/2008

Therapy/Procedure

64	Therapeutics 05/2022 - 02/2002
3	Precision Medicine 01/2021 - 01/2020
3	Cardiopulmonary Bypass (Heart-Lung Bypass) 11/2018 - 03/2004